Native Americans roamed the area freely before Arkansas was a territory. The Cherokee and Osage lived in this area that would later become attractive to settlers.[8] The Ozark area was frequented by French fur trappers and served as a landmark during European exploration of the area. It was these adventurous souls who gave the area and the rolling mountains that rise there their name, Aux Arcs.
Included in the Louisiana Purchase of 1803, the vicinity became a stopping and crossing point along the Arkansas River. The modern settlement of Ozark was established here in the 1830s, and an important road grew connecting Ozark to Fayetteville, Arkansas, following the route of today's Pig Trail Scenic Byway to connect Northwest Arkansas with the river.
Ozark played a role on the Trail of Tears. Steamboats would often stop here in times of low water and Native Americans camped in Ozark before moving to Oklahoma on foot. The waterfront is a designated stop on the trail of tears route.
Ozark's population grew to about 100 people during the Civil War and served as a Confederate base after the battles of Pea Ridge and Prairie Grove in 1862. In April 1863, Brigadier General William L. Cabell led 900 men from Ozark on an expedition that ended at the Battle of Fayetteville. Ozark became the scene of fighting later that year and again in 1864, where many skirmishes were fought in the vicinity. A monument on the grounds of the Franklin County Courthouse pays tribute to an officer killed just north of town.
Although Ozark prospered over the years, it remained a small city on the river.[9]
The name "Ozark" comes from Aux Arcs, the name given to the area and the mountains that rise there by early French settlers. Ozark, Arkansas, was the first community to be incorporated with that name.[10]